Morphine Can Protect The Brains Of People Suffering From HIV Infection

Morphine Can Protect The Brains Of People Suffering From HIV Infection.
The analgesic morphine may lend a hand protect against HIV-associated dementia, says a further study theanine. Georgetown University Medical Center researchers found that morphine protected rat neurons from HIV toxicity, a uncovering that could lead to the development of new drugs to treat common man with HIV-related dementia, which causes depression, anxiety and physical and mental problems.

So "We think that morphine may be neuroprotective in a subset of people infected with HIV," lead investigator Italo Mocchetti, a professor of neuroscience, said in a Georgetown report release. He and his colleagues conducted the inspect because they knew that some people with HIV who are heroin users never develop HIV brain dementia trichozed hair falls treatment. Morphine is like to heroin.

In their tests on rats, the researchers found that morphine triggers brain cells called astrocytes to deliver a protein called CCL5, which activates factors that suppress HIV infection in protected cells. CCL5 "is known to be important in blood, but we didn't know it is secreted in the brain. Our supposition is that it is in the brain to prevent neurons from dying".

The study was to be presented at the annual junction of the Society of NeuroImmune Pharmacology, April 13 to 17 in Manhattan Beach, Calif. "Ideally, we can use this info to develop a morphine-like compound that does not have the typical dependency and tolerance issues that morphine has".

Austrian Scientists Have Determined The Effect Of Morphine On Blood Coagulation

Austrian Scientists Have Determined The Effect Of Morphine On Blood Coagulation.
Morphine appears to break the effectiveness of the commonly Euphemistic pre-owned blood-thinning stimulant Plavix, which could hamper emergency-room efforts to treat heart attack victims, Austrian researchers report. The decision could create serious dilemmas in the ER, where doctors have to weigh a enthusiasm patient's intense pain against the need to break up and prevent blood clots, said Dr Deepak Bhatt, official director of interventional cardiovascular programs at Brigham and Women's Hospital Heart and Vascular Center, in Boston length. "If a diligent is having crushing heart pain, you can't just describe them to tough it out, and morphine is the most commonly used medication in that situation," said Bhatt, who was not active in the study.

And "Giving them morphine is the humane thing to do, but it could also create delays in care". Doctors will have to be notably careful if a heart attack patient needs to have a stent implanted. Blood thinners are momentous in preventing blood clots from forming around the stent online. "If that locale is unfolding, it requires a little bit of extra thought on the part of the physician whether they want to give that full slug of morphine or not".

About half of the 600000 stent procedures that pilfer place in the United States each year take place as the result of a heart attack, angina or other acute coronary syndrome. The Austrian researchers focused on 24 nutritious people who received either a dose of Plavix with an injection of morphine or a placebo drug. Morphine delayed the gift of Plavix (clopidogrel) to thin a patient's blood by an general of two hours, the researchers said.